Study of bone marrow: dyserythropoiesis for etiological evaluation of anemia

Background: Bone Marrow Aspiration plays a major role in the diagnosis of various hematolgical disorders which are very frequent in various age groups. The aim of this study was to analyze the causes of haematological disorders, and to interpret the bone marrow aspiration findings with various dyserythropoietic changes in it.Methods: This was a study carried out in the department of Pathology of Shri M P Shah Govt. Medical college over a period of two years from June 2008 to June 2010. Bone marrow examination of 100 cases of suspected haematological disorders was carried out. All details of the patients were the recorded in the department of pathology.Results: Out of 100 cases of bone marrow aspiration, erythroid hyperplasia and megaloblastic changes were commonest findings and Megaloblastic anemia was most common diagnosis given on bone marrow examination. Other dyserythropoietic changes were erythroidhypoplasia, micronormoblasts, dimorphic erythropoiesis, megaloblastoid changes and other like – cytoplasmic bleb, multinucleation,nuclear bridging.Conclusions: The sincere blood film examination and keen morphological evaluation of erythroid series for dyserythropiesis   and  leukopoesis and  megakaryopiesis in bone marrow aspiration smear - supported with   other investigation can navigate to etiological factors of anaemia and other haematological disorders.

Aspergillosis in poultry

<p>Avian Aspergillosis is the major mycotic non-contagious disease of birds. It is also known as brooder pneumonia. It is mainly the disease of respiratory system affecting domestic poultry, wild birds and zoo birds. This is considered as disease of typical mishandling of birds mainly backyard and commercial poultry. The aspergillosis is mainly caused by Aspergillus fumigatus fungus, however other species such as A. flavus, A. niger, A. nidulans, and A. terreus may also be isolated from cases of aspergillosis in birds (occasionally in mixed infections).</p&gt

Modeling the dynamics of mouse iron body distribution: hepcidin is necessary but not sufficient

Abstract Background Iron is an essential element of most living organisms but is a dangerous substance when poorly liganded in solution. The hormone hepcidin regulates the export of iron from tissues to the plasma contributing to iron homeostasis and also restricting its availability to infectious agents. Disruption of iron regulation in mammals leads to disorders such as anemia and hemochromatosis, and contributes to the etiology of several other diseases such as cancer and neurodegenerative diseases. Here we test the hypothesis that hepcidin alone is able to regulate iron distribution in different dietary regimes in the mouse using a computational model of iron distribution calibrated with radioiron tracer data. Results A model was developed and calibrated to the data from adequate iron diet, which was able to simulate the iron distribution under a low iron diet. However simulation of high iron diet shows considerable deviations from the experimental data. Namely the model predicts more iron in red blood cells and less iron in the liver than what was observed in experiments. Conclusions These results suggest that hepcidin alone is not sufficient to regulate iron homeostasis in high iron conditions and that other factors are important. The model was able to simulate anemia when hepcidin was increased but was unable to simulate hemochromatosis when hepcidin was suppressed, suggesting that in high iron conditions additional regulatory interactions are important